The below comparison matrix shows many of the detailed differences between several of the most popular Node.js based CMS and application frameworks. Needless to say, take this with a grain of salt and only use this content to short list the option(s) that best align with your business requirements.
With all complex systems, "the devil is in the details" so its always preferable to perform a POC on one or more of your top choices before making a final decision. A week spent on a POC can save months of throw away work in potential situations where you don't learn about the shortcomings of a system until you are deep into the implementation phase of your project. In other words, don't let the 80/20 rule get the best of you!